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GlaxoSmithKline sued Pfizer on Wednesday over patent infringement, alleging the US drugmaker's RSV vaccine steals key elements of the British company's version.

A US credit downgrade by Fitch was "entirely unwarranted," Treasury Secretary Janet Yellen said Wednesday, pushing back against the second-ever decrease by a major ratings agency following repeated debt limit standoffs in Washington.

Argentine footballer Luciano Sanchez could be out of action for up to a year after his left knee was entirely dislocated in a chilling injury the likes of which his doctor said he has never seen.

Pope Francis said on Wednesday that the "anguished cry" of clerical sexual abuse victims must be heard as he began a five-day visit to Portugal for a major Catholic youth festival.

Canadian Prime Minister Justin Trudeau announced Wednesday that he and his wife of 18 years, Sophie Gregoire-Trudeau, are separating.

A Tunisian singer who rose to prominence during the Arab Spring revolution in her homeland announced Wednesday an upcoming show in Tunisia had been cancelled for supposed "normalisation" with Israel.

"It was compelling," Joe Biden offered Tuesday after Donald Trump's indictment. But the US president was referring to a film -- not the legal fate of his political rival, which he has declined to address.

Donald Trump's historic indictment for trying to overturn the 2020 election paints a picture of a former president so determined to hang on to power that he put the very foundations of American democracy at risk.

Former world number one Justin Thomas is just one of the former major champions making a last-ditch bid at the Wyndham Championship this week to turn around a disappointing season.

Hungarian low-cost airline Wizz Air has ordered another 75 A321neo aircraft, Airbus said Wednesday, in a deal worth $10 billion at list prices.

Robert Bowers, an American truck driver, was sentenced to death on Wednesday for massacring 11 Jewish worshippers five years ago in the deadliest anti-Semitic attack in US history.

Tunisian President Kais Saied fired his prime minister Najla Bouden without explanation late Tuesday. Why did he do this, and what are the implications for the debt-ridden North African country?

Global stock markets slumped Wednesday after the United States had its top credit rating downgraded by Fitch.

Irish super horse Paddington powered through the rain to win the Sussex Stakes at 'Glorious Goodwood' on Wednesday to record his fourth successive Group One success.

Russia's supreme court on Wednesday rejected an appeal by prominent investigative journalist Ivan Safronov against his 22-year prison sentence for high treason.

Senegal on Wednesday suspended TikTok, saying the video-sharing platform had been used to fan violence sparked by the detention of opposition figure Ousmane Sonko.

Italy's 2006 World Cup-winning goalkeeper Gianluigi Buffon announced his retirement on Wednesday at the age of 45, sparking tributes from the world of football.

Italy's 2006 World Cup-winning goalkeeper Gianluigi Buffon announced his retirement on Wednesday at the age of 45, sparking tributes from the world of football.

Manchester City have agreed a fee of 90 million euros with RB Leipzig for Croatia international defender Josko Gvardiol, Sky and the BBC reported on Wednesday.

Look out, blue whale -- there's a new contender for your heavyweight title.

Captain Thembi Kgatlana, who scored the injury-time goal on Wednesday that took South Africa into the Women's World Cup last 16, revealed afterwards that three family members have died in recent weeks.

Senegal has been plunged into uncertainty over who could become the next president, seven months ahead of elections, after the incumbent confirmed he would not run and his chief opponent was indicted.

Nigerian workers across numerous sectors went on strike Wednesday over the rising cost of living following the removal of a petrol subsidy.

Europe captain Luke Donald has named former skipper Jose Maria Olazabal as his fourth vice-captain for this year's Ryder Cup in Rome.

West Africa's regional bloc on Wednesday said a military intervention in junta-ruled Niger was "the last resort" as Nigeria cut electricity supplies to intensify pressure on the country's coup leaders.

Gianluigi Buffon announced his retirement from football on Wednesday, bringing down the curtain on a glorious career as one of the world's greatest ever goalkeepers.

Jamaica dumped out Brazil and South Africa sent Italy home on Wednesday as the supposed minnows roared into the last 16 of an increasingly open Women's World Cup.

Panama coach Nacho Quintana said Wednesday their first-ever World Cup goals in a 6-3 defeat to France will be a springboard to growing the game in their home nation.

Italy's 2006 World Cup-winning goalkeeper Gianluigi Buffon announced his retirement on Wednesday at the age of 45.

Hiring in the US private sector decelerated in July but was nearly twice as high as analysts expected according to payroll firm ADP on Wednesday, signaling strength in the jobs market.

Pope Francis urged Europe to act as a "bridge and peacemaker" to end the war in Ukraine on Wednesday, as he opened a five-day visit to Portugal for a major Catholic youth festival.

Marta said Brazil's Women's World Cup exit at the group stage Wednesday was "not even in my worst nightmares" as the legendary attacker bid a heartbreaking farewell to the tournament.